Extrarenal erythropoietin production by the liver in the weanling rat
Journal Article
·
· Proc. Soc. Exp. Biol. Med.; (United States)
Erythropoietin production is considerably reduced but not abolished in adult rats exposed to hypoxia immediately after nephrectomy, whereas in young weanling rats exposed to hypoxia, removal of the kidneys has little effect on the production of the hormone. Thus, the hormone is produced or activated by extrarenal as well as renal tissues. Fried has recently presented evidence implicating the liver as a site of extrarenal erythropoietin production in the adult anephric rat. In the present paper, evidence will be presented that the liver is normally an important site of erythropoietin production or activation in the weanling rat exposed to hypoxia.
- Research Organization:
- Univ. of California, Berkeley
- OSTI ID:
- 6548824
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 145; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice
In vivo metabolism of recombinant human erythropoietin in the rat
Erythropoietin messenger RNA levels in developing mice and transfer of /sup 125/I-erythropoietin by the placenta
Journal Article
·
Tue Oct 01 00:00:00 EDT 1991
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:5604494
In vivo metabolism of recombinant human erythropoietin in the rat
Journal Article
·
Sat Dec 31 23:00:00 EST 1988
· Blood; (United States)
·
OSTI ID:6499920
Erythropoietin messenger RNA levels in developing mice and transfer of /sup 125/I-erythropoietin by the placenta
Journal Article
·
Fri Jul 01 00:00:00 EDT 1988
· J. Clin. Invest.; (United States)
·
OSTI ID:7188163