Airborne arsenic exposure and excretion of methylated arsenic compounds
Journal Article
·
· Environ. Health Perspect.; (United States)
First void urine samples were collected from copper smelter workers exposed to inorganic arsenic and from unexposed controls. Arsenic compounds (As(III), As(V), methylarsonic acid and dimethylarsinic acid) in these samples were analyzed by selective volatilization as arsines with determination of arsenic by plasma excitation emission spectrometry. On the day preceding the urine sample collection a breathing zone measurement was made of respirable arsenic particulates for each subject. It was found that all of the subjects, including the controls excreted arsenic primarily as methylated species. Approximately 50% of the total arsenic was excreted as dimethylarsinic acid and 20% as methylarsonic acid. Slight differences in the proportion of various arsenic compounds were observed with varying levels of inorganic arsenic exposure. Amounts of arsenic species were all closely correlated with each other and with exposure. Irrespirable particulate exposures were measured on a subset of high exposure workers. Irrespirable arsenic was found to be more closely correlated with excretion of arsenic compounds than was respirable arsenic.
- Research Organization:
- Univ. of Utah, Salt Lake City
- OSTI ID:
- 6545646
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 19; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARSENIC COMPOUNDS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
CLEARANCE
COPPER
DIFFUSION
ECOLOGICAL CONCENTRATION
ELEMENTS
EXCRETION
GASEOUS WASTES
INHALATION
INTAKE
MAMMALS
MAN
MATERIALS
METABOLISM
METALS
METHYLATION
OCCUPATIONAL EXPOSURE
PARTICLES
PARTICULATES
PRIMATES
RESPIRATION
SMELTERS
TRANSITION ELEMENTS
URINE
VERTEBRATES
WASTES
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARSENIC COMPOUNDS
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
CLEARANCE
COPPER
DIFFUSION
ECOLOGICAL CONCENTRATION
ELEMENTS
EXCRETION
GASEOUS WASTES
INHALATION
INTAKE
MAMMALS
MAN
MATERIALS
METABOLISM
METALS
METHYLATION
OCCUPATIONAL EXPOSURE
PARTICLES
PARTICULATES
PRIMATES
RESPIRATION
SMELTERS
TRANSITION ELEMENTS
URINE
VERTEBRATES
WASTES