Mechanism of histamine release from human basophils

Conference · Sat Dec 31 23:00:00 EST 1977

OSTI ID:6541683

Dembo, M; Goldstein, B

The theory of histamine release of Dembo, Goldstein, Sobotka, and Lichtenstein is able to explain a variety of kinetic experiments in a self consistent and quantitative way. The principal elements of the theory are: the histamine content of basophils is divided into a large number of discrete and independent quanta; release of the contents of a quanta is a stochastic event; a certain fraction of the quanta in a population of basophils is nonreleasable; the probability per unit time, P/sub R/, of the release event is a sigmoid function of the number of crosslinked IgE molecules on the cell surface. In addition, P/sub R/ goes to zero when the extracellular calcium concentration goes to zero; and specific desensitization is due to the action of a degradative enzyme on cell surface IgE molecules which are crosslinked to other cell surface IgE molecules. Furthermore, this enzyme is unaffected by the calcium concentration.

• Research Organization: Los Alamos Scientific Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6541683
• Report Number(s): LA-UR-78-2561; CONF-781070-2
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550300* -- Cytology
551000 -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH METALS
AMINES
AZOLES
BASOPHILS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CALCIUM
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL REACTIONS
CROSS-LINKING
ELEMENTS
ENZYME ACTIVITY
GLOBULINS
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
IMMUNOGLOBULINS
KINETICS
LEUKOCYTES
MEMBRANES
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLYMERIZATION
PROTEINS
REACTION KINETICS
SECRETION
STOCHASTIC PROCESSES