Prevalence of. cap alpha. /sub 1/-antitrypsin heterozygotes (Pi MZ) in patients with obstructive pulmonary disease

Journal Article · Thu Jan 01 00:00:00 EST 1976 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:6541223

Shigeoka, J W; Hall, W J; Hyde, R W; Schwartz, R H; Mudholkar, G S; Speers, D M; Lin, C C

An increased incidence of intermediate deficiency of serum ..cap alpha../sub 1/-antitrypsin resulting from Pi phenotype MZ has been reported in patients with chronic obstructive pulmonary disease (COPD) by some laboratories but not confirmed by others. Prevalence of Pi MZ was determined in patients with COPD among 502 subjects referred to a pulmonary function testing laboratory in a region with low concentrations of air pollutants. Control prevalences were obtained from 930 randomly selected subjects in the same community as well as from patients without COPD referred to the laboratory. Depending on criteria used to define COPD, 155 to 306 subjects had COPD. Pi MZ prevalence in subjects with COPD varied from 1.5 to 4 times the prevalence in the community control group and in the patients without COPD. This difference approached significance or was significant. Because Pi MZ was present in only 3.5 to 4.5% of patients with COPD, Pi MZ is not a major factor in the etiology of COPD in this community. The higher incidence of Pi MZ in patients with COPD reported by other investigators may be explained by small sample size, bias in selection of study or control population groups, or the development of COPD from interaction between Pi MZ and air pollutants or other factors not present in this community.

• Research Organization: Univ. of Rochester School of Medicine and Dentistry, NY
• OSTI ID: 6541223
• Journal Information: Am. Rev. Respir. Dis.; (United States), Vol. 114
• Country of Publication: United States
• Language: English

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