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Title: Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma

Abstract

To investigate cardiopulmonary function in progressive systemic sclerosis with diffuse scleroderma, we studied 26 patients with maximal exercise and redistribution thallium scans, rest and exercise radionuclide ventriculography, pulmonary-function testing, and chest roentgenography. Although only 6 patients had clinical evidence of cardiac involvement, 20 had abnormal thallium scans, including 10 with reversible exercise-induced defects and 18 with fixed defects (8 had both). Seven of the 10 patients who had exercise-induced defects and underwent cardiac catheterization had normal coronary angiograms. Mean resting left ventricular ejection fraction and mean resting right ventricular ejection fraction were lower in patients with post-exercise left ventricular thallium defect scores above the median (59 +/- 13 per cent vs. 69 +/- 6 per cent, and 36 +/- 12 per cent vs. 47 +/- 7 per cent, respectively). The authors conclude that in progressive systemic sclerosis with diffuse scleroderma, abnormalities of myocardial perfusion are common and appear to be due to a disturbance of the myocardial microcirculation. Both right and left ventricular dysfunction appear to be related to this circulatory disturbance, suggesting ischemically mediated injury.

Authors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of Pittsburgh School of Medicine, PA
OSTI Identifier:
6541141
Resource Type:
Journal Article
Resource Relation:
Journal Name: N.Engl. J. Med.; (United States); Journal Volume: 310:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARDIOVASCULAR DISEASES; DIAGNOSIS; LUNGS; SCINTISCANNING; THALLIUM ISOTOPES; TISSUE DISTRIBUTION; PATIENTS; BODY; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; DISTRIBUTION; ISOTOPES; ORGANS; RADIOISOTOPE SCANNING; RESPIRATORY SYSTEM; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Follansbee, W.P., Curtiss, E.I., Medsger, T.A. Jr., Steen, V.D., Uretsky, B.F., Owens, G.R., and Rodnan, G.P. Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma. United States: N. p., 1984. Web. doi:10.1056/NEJM198401193100302.
Follansbee, W.P., Curtiss, E.I., Medsger, T.A. Jr., Steen, V.D., Uretsky, B.F., Owens, G.R., & Rodnan, G.P. Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma. United States. doi:10.1056/NEJM198401193100302.
Follansbee, W.P., Curtiss, E.I., Medsger, T.A. Jr., Steen, V.D., Uretsky, B.F., Owens, G.R., and Rodnan, G.P. Thu . "Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma". United States. doi:10.1056/NEJM198401193100302.
@article{osti_6541141,
title = {Physiologic abnormalities of cardiac function in progressive systemic sclerosis with diffuse scleroderma},
author = {Follansbee, W.P. and Curtiss, E.I. and Medsger, T.A. Jr. and Steen, V.D. and Uretsky, B.F. and Owens, G.R. and Rodnan, G.P.},
abstractNote = {To investigate cardiopulmonary function in progressive systemic sclerosis with diffuse scleroderma, we studied 26 patients with maximal exercise and redistribution thallium scans, rest and exercise radionuclide ventriculography, pulmonary-function testing, and chest roentgenography. Although only 6 patients had clinical evidence of cardiac involvement, 20 had abnormal thallium scans, including 10 with reversible exercise-induced defects and 18 with fixed defects (8 had both). Seven of the 10 patients who had exercise-induced defects and underwent cardiac catheterization had normal coronary angiograms. Mean resting left ventricular ejection fraction and mean resting right ventricular ejection fraction were lower in patients with post-exercise left ventricular thallium defect scores above the median (59 +/- 13 per cent vs. 69 +/- 6 per cent, and 36 +/- 12 per cent vs. 47 +/- 7 per cent, respectively). The authors conclude that in progressive systemic sclerosis with diffuse scleroderma, abnormalities of myocardial perfusion are common and appear to be due to a disturbance of the myocardial microcirculation. Both right and left ventricular dysfunction appear to be related to this circulatory disturbance, suggesting ischemically mediated injury.},
doi = {10.1056/NEJM198401193100302},
journal = {N.Engl. J. Med.; (United States)},
number = ,
volume = 310:3,
place = {United States},
year = {Thu Jan 19 00:00:00 EST 1984},
month = {Thu Jan 19 00:00:00 EST 1984}
}