Regulation of nucleic acid and protein synthesis: a background study related to the biological effects of radiation. Progress report
Technical Report
·
OSTI ID:6540389
Progress is reported in the following areas in defining the varied roles of diadenosine 5', 5'''-P/sup 1/, P/sup 4/-tetraphosphate (Ap/sub 4/A) in metabolic events within the living cell: (1) Ap/sub 4/A association with a subunit of DNA polymerase ..cap alpha..; (2) studies on the unusual ordered structure of Ap/sub 4/A and of related bisnucleoside oligophosphates; (3) the utilization of technetium labeled Ap/sub 4/A as a radionuclide diagnostic reagent; and (4) the role of Ap/sub 4/A in the blood clotting mechanism. (ACR)
- Research Organization:
- Worcester Foundation for Experimental Biology, Shrewsbury, MA (USA)
- DOE Contract Number:
- AC02-80EV10326
- OSTI ID:
- 6540389
- Report Number(s):
- DOE/EV/10326-1; ON: DE84017097
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BLOOD COAGULATION
DNA-ASE
ENZYMES
ESTERASES
FUNCTIONS
HOURS LIVING RADIOISOTOPES
HYDROLASES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
METABOLISM
MOLECULAR STRUCTURE
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHODIESTERASES
PHOSPHORUS COMPOUNDS
RADIOISOTOPES
RESEARCH PROGRAMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BLOOD COAGULATION
DNA-ASE
ENZYMES
ESTERASES
FUNCTIONS
HOURS LIVING RADIOISOTOPES
HYDROLASES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLING
METABOLISM
MOLECULAR STRUCTURE
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHODIESTERASES
PHOSPHORUS COMPOUNDS
RADIOISOTOPES
RESEARCH PROGRAMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES