Cerebral blood flow and red cell delivery in normal subjects and in multiple sclerosis

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Neurol. Res.; (United States)

OSTI ID:6540111

Swank, R L; Roth, J G; Woody, Jr, D C

Regional cerebral blood flow (rCBF) was determined in 77 normal females and 53 normal males of different ages and in 26 men and 45 women with multiple sclerosis by the inhalation of radioactive Xe133 method. In the normal subjects the CBF was relatively high in the teens and fell, at first rapidly and then slowly in both sexes with age. During adult life the flow in females was significantly higher than in males. The delivery of packed red cells (RCD) was determined by multiplying the CBF by the percentage concentration of red cells (HCT). The RCD for both sexes was nearly the same. In the patients with multiple sclerosis there occurred a progressive generalized decrease in CBF and in RCD with age which was significantly greater than observed in normal subjects. The rate of decrease in CBF and RCD correlated directly with the rate of progress of the disease.

• Research Organization: Oregon Health Sciences Univ., Portland
• OSTI ID: 6540111
• Journal Information: Neurol. Res.; (United States), Vol. 5:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD FLOW
MEASURING METHODS
BRAIN
BLOOD CIRCULATION
ERYTHROCYTES
BIOCHEMICAL REACTION KINETICS
NERVOUS SYSTEM DISEASES
DIAGNOSIS
AGE DEPENDENCE
INHALATION
PATIENTS
SEX DEPENDENCE
TRACER TECHNIQUES
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
EVEN-ODD NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MATERIALS
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
REACTION KINETICS
XENON ISOTOPES
551001* - Physiological Systems- Tracer Techniques