Hematotoxicity of inhaled benzene to Sprague-Dawley rats and AKR mice at 300 PPM

Journal Article · Sun Jan 01 04:00:00 EST 1978 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397809529683· OSTI ID:6539430

Synder, C A ^[1]; Goldstein, B D; Sellakumar, A; Wolman, S R; Bromberg, I; Erlichman, M N; Laskin, S

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1. New York Univ., Tuxedo

Sprague-Dawley rats and AKR/J mice were exposed to 300 ppM benzene vapor for 6 h/d, 5 d/wk, for life. Rats exhibited lymphocytopenia, mild anemia, and moderately decreased survival. Mice showed severe lymphocytopenia and anemia accompanied by granulocytosis and reticulocytosis. Treated mice also showed significantly decreased survival and weight gain. No indications of a leukemic or preleukemic response were observed in either species.

• OSTI ID: 6539430
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABUNDANCE
ANEMIAS
ANIMALS
AROMATICS
BENZENE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DISEASES
HEMIC DISEASES
HYDROCARBONS
INHALATION
INTAKE
LEUKOCYTES
LEUKOPENIA
LYMPHOPENIA
MAMMALS
MICE
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
RATS
RODENTS
SURVIVAL TIME
SYMPTOMS
TOXICITY
VERTEBRATES