Effects of prenatal X irradiation on the appearance of reflexes and physiologic markers in the neonatal rat

Journal Article · Wed Nov 30 23:00:00 EST 1988 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577385· OSTI ID:6536986

Jensh, R P; Brent, R L

Seventy pregnant adult Wistar strain rats were randomly assigned to 1 of 12 exposure groups; 9th or 17th day irradiation at the 0-, 0.1-, 0.2-, 0.4-, 0.6-, or 0.8-Gy dosage level. On the first day of postnatal life, litters were reduced to a maximum of eight pups per litter. A total of 508 pups were observed for the age of acquisition of five reflexes (air righting, surface righting, visual placing, negative geotaxis, auditory startle) and the appearance of four physiologic markers (pinna detachment, eye opening, vaginal opening, testes descent). A dose-response relationship for alterations in reflex acquisition and physiologic marker appearance was observed due to exposure above 0.2 Gy on the 17th day of gestation. Therefore, 0.2 to 0.4-Gy exposure may represent a threshold range for exposure on the 17th day using these postnatal parameters.

• Research Organization: Thomas Jefferson Univ., Philadelphia, PA (USA)
• OSTI ID: 6536986
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 116:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMAL GROWTH
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MARKERS
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
GROWTH
IONIZING RADIATIONS
MAMMALS
NEONATES
PREGNANCY
PRENATAL EXPOSURE
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RATS
REFLEXES
RODENTS
THRESHOLD DOSE
VERTEBRATES
X RADIATION