Retention of /sup 239/Pu in the mouse lung and estimation of consequent dose following inhalation of sized /sup 239/PuO/sub 2/
The retention of /sup 239/Pu in the lungs of SAS/4 mice following inhalation exposure to sized /sup 239/PuO/sub 2/ particles is described. When the initial alveolar deposition (IAD) was <200 Bq, retention of /sup 239/Pu could be described by a two-component exponential expression, about 90% being cleared with a half-time of about 40 days and the remainder with a half-time of about 150 days. Similar amounts of /sup 239/Pu were retained up to 3 months with IADs>800 Bq, but clearance was impaired thereafter, the half-time of the second component increasing to about 720 days. The retention of /sup 239/Pu was independent of the particle size of the administered /sup 239/PuO/sub 2/. Studies of the retention of /sup 239/Pu by individual lobes indicated that there were intrinsic interlobar differences which were enhanced at higher IADs. Lung clearance was also studied by the measurement of /sup 239/Pu in feces excreted by groups of mice in the period immediately prior to sacrifice. The estimation of radiation dose to lung is discussed.
- Research Organization:
- AERE, Harwell, England
- OSTI ID:
- 6536904
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CHALCOGENIDES
CLEARANCE
DATA
DOSES
EVEN-ODD NUCLEI
EXCRETION
EXPERIMENTAL DATA
FECES
FUNCTIONS
HEAVY NUCLEI
INFORMATION
INHALATION
INTAKE
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MATERIALS
MICE
NUCLEI
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
PLUTONIUM 239
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM OXIDES
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
RETENTION FUNCTIONS
RODENTS
TRANSURANIUM COMPOUNDS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES