Higher density of serotonin-1A receptors in the hippocampus and cerebral cortex of alcohol-preferring P rats
- Lilly Research Laboratories, Indianapolis, IN (USA)
- Indiana Univ., Indianapolis (USA)
Saturable ({sup 3}H)-80HDPAT binding to 5HT-1A receptors in membranes prepared from hippocampus and frontal cerebral cortex of alcohol-preferring (P) rats and of alcohol-nonpreferring (NP) rats has been compared. The B{sub max} values or densities of recognition sites for 5HT-1A receptors in both brain areas of the P rats are 38 and 44 percent lower in the P rats than in the NP rats. The corresponding K{sub D} values are 38 and 44 percent lower in the P rats than in the NP rats, indicating higher affinities of the recognition sites for the 5HT-1A receptors in hippocampus and cerebral cortex of the P rats. These findings indicate either an enrichment of 5HT-1A receptor density during selective breeding for alcohol preference or an upregulation of 5HT-1A receptors of 5HT found in these brain areas of P rats as compared with the NP rats.
- OSTI ID:
- 6528538
- Journal Information:
- Life Sciences; (USA), Journal Name: Life Sciences; (USA) Vol. 46:3; ISSN 0024-3205; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Tritium-3-N-methylspiperone labels D2 dopamine receptors in basal ganglia and S2 serotonin receptors in cerebral cortex
Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
550600 -- Medicine
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
AMINES
ANATOMY
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
AZAARENES
AZOLES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DISTRIBUTION
DRUGS
ETHANOL
HETEROCYCLIC COMPOUNDS
HIPPOCAMPUS
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
ISOTOPE APPLICATIONS
KINETICS
MEMBRANE PROTEINS
MENTAL DISORDERS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RECEPTORS
SEROTONIN
SYMPATHOMIMETICS
TETRALIN
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TRYPTAMINES