The spectrum of pheochromocytoma in hypertensive patients with neurofibromatosis

Journal Article · Mon Nov 01 00:00:00 EST 1982 · Arch. Intern. Med.; (United States)

DOI:https://doi.org/10.1001/archinte.1982.00340250050010· OSTI ID:6528106

Kalff, V; Shapiro, B; Lloyd, R; Sisson, J C; Holland, K; Nakajo, M; Beierwaltes, W H

We have found an appreciable number of pheochromocytomas in patients with neurofibromatosis and concurrent hypertension (ten of 18 cases). At diagnosis, the patient age range was 15 to 62 years, the clinical appearance of the neurofibromatosis did not predict who would and who would not have pheochromocytomas, but the age at diagnosis was helpful in that our younger patients tended to have causes of hypertension other than pheochromocytoma. However, several causes of hypertension may coexist. The biochemical findings were highly diagnostic. The pheochromocytomas secreted epinephrine as well as norepinephrine and resided in or next to the adrenal gland. Where pheochromocytoma is the cause of hypertension, its resection generally results in a better control of hypertension than that obtained in patients whose BPs were elevated from other unknown causes.

• Research Organization: Division of Nuclear Medicine, University of Michigan, Ann Arbor
• OSTI ID: 6528106
• Journal Information: Arch. Intern. Med.; (United States), Vol. 142:12
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HYPERTENSION
PATHOLOGY
NEOPLASMS
ADRENAL GLANDS
ADRENALINE
BLOOD PRESSURE
DIAGNOSIS
FIBROSIS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NORADRENALINE
PATIENTS
ADRENAL HORMONES
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
DISEASES
DRUGS
ENDOCRINE GLANDS
GLANDS
HORMONES
NEUROREGULATORS
ORGANS
PATHOLOGICAL CHANGES
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
VASCULAR DISEASES
550900* - Pathology
551000 - Physiological Systems
550200 - Biochemistry