Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Journal Article · Fri Sep 30 00:00:00 EDT 1994 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.8091231· OSTI ID:6526656

Wooster, R; Mangion, J; Quirk, Y; Collins, N; Seal, S; Ford, D; Averill, D ^[1]; Neuhausen, S L; Nguyen, K; Tran, T ^[2]

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1. Institute of Cancer Research, Surrey (United Kingdom)
2. Univ. of Utah, Salt Lake City, UT (United States); and others

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary, evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

• OSTI ID: 6526656
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 265:5181; ISSN SCIEAS; ISSN 0036-8075
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BODY
CHROMOSOMES
CONTROL
DISEASES
GENES
GENETIC CONTROL
GENETIC MAPPING
GLANDS
HUMAN CHROMOSOME 13
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
HUMAN POPULATIONS
MAMMARY GLANDS
MAPPING
NEOPLASMS
ORGANS
PEST CONTROL
POPULATIONS