Role of bone marrow cells in the growth inhibition of transplanted methylcholanthrene-induced sarcoma (MCA). [/sup 137/Cs]

Conference · Sun Mar 01 04:00:00 EST 1981 · Transplant. Soc., Int. Cong., Proc.; (United States)

OSTI ID:6525299

Scuderi, P; Rosse, C

The operation of various antitumor mechanisms in vivo remains largely unknown. The presence of specific sensitized cells in the spleen and lymph node of tumor-bearing and tumor-immune animals has been demonstrated. Such cells are more effectively revealed by secondary sensitization of the splenocytes of tumor-immune animals in vitro by reexposing them to the tumor. Tumor-immune in vitro sensitized splenocytes (ISS) are highly effective in retarding the in vivo growth of the sensitizing tumor when they are transplated together with tumor cells into normal recipient mice. However, if the same cell transfer is made into lethally irradiated mice, the tumor will grow rapidly in 100% of recipients. The objective of the present study is to explore this phenomenon and to determine the origin of the host cells that are capable of collaborating with tumor-immune in vitro sensitized splenocytes in the regulation of tumor growth. We designed experiments to test whether the host cells involved in tumor growth regulation are derived from the spleen, thymus, or the bone marrow and set out to determine whether or not collaboration of the host cells with ISS was specific as far as the sensitizing tumor was concerned.

• Research Organization: Univ. of Washington, Seattle
• DOE Contract Number: EY-76-S-06-2225
• OSTI ID: 6525299
• Conference Information: Journal Name: Transplant. Soc., Int. Cong., Proc.; (United States) Journal Volume: 13:1
• Country of Publication: United States
• Language: English

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560152* -- Radiation Effects on Animals-- Animals
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BONE MARROW CELLS
CELL KILLING
CESIUM 137
CESIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTROMAGNETIC RADIATION
EVALUATION
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXTERNAL IRRADIATION
GAMMA RADIATION
GROWTH
HALIDES
HALOGEN COMPOUNDS
INHIBITION
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LETHAL IRRADIATION
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SARCOMAS
SOMATIC CELLS
SPLEEN CELLS
STABLE ISOTOPES
STRONTIUM 88
STRONTIUM 89
STRONTIUM CHLORIDES
STRONTIUM COMPOUNDS
STRONTIUM ISOTOPES
THYMOCYTES
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES