Genetic toxicology of putative nongenotoxic carcinogens

Technical Report · Fri Jan 01 04:00:00 EST 1993

OSTI ID:6525153

Jackson, M A; Stack, H F; Waters, M D

The report examines a group of putative nongenotoxic carcinogens that have been cited in the published literature. Using short-term test data from the US Environmental Protection Agency/International Agency for Research on Cancer genetic activity profile (EPA/IARC GAP) database, these agents are classified on the basis of their mutagenicity emphasizing three genetic endpoints: gene mutation, chromosomal aberration and aneuploidy. On the basis of results of short-term tests for these effects, criteria was defined for evidence of mutagenicity (and nonmutagenicity) these criteria were applied in classifying the group of putative nongenotoxic carcinogens. The results from this evaluation based on the EPA/IARC GAP database are presented along with a summary of the short-term test data for each chemical and the relevant carcinogenicity results from the NTP, Gene-Tox and IARC databases. The data clearly demonstrate that many of the putative nongenotoxic carcinogens that have been adequately tested in short-term bioassays induce gene or chromosomal mutations or aneuploidy.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
• OSTI ID: 6525153
• Report Number(s): PB-93-175636/XAB; EPA--600/J-93/094
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEUPLOIDY
CARCINOGENS
CHEMISTRY
CHROMOSOMAL ABERRATIONS
DEVELOPED COUNTRIES
GENE MUTATIONS
GLOBAL ASPECTS
HUMAN POPULATIONS
MUTATIONS
NATIONAL ORGANIZATIONS
NORTH AMERICA
ORGANIC COMPOUNDS
PLOIDY
POPULATIONS
RESEARCH PROGRAMS
SAFETY STANDARDS
STANDARDS
TOXICITY
US EPA
US ORGANIZATIONS
USA