Human upper respiratory tract responses to inhaled pollutants with emphasis on nasal lavage
Technical Report
·
OSTI ID:6524130
A set of symptoms has been described during the past two decades which has been called the sick building syndrome. These symptoms include eye, nose, and throat irritation; headache; mental fatigue; and respiratory distress. It is likely that volatile organic compounds (VOC) present in synthetic materials used in homes and office buildings contribute to these symptoms. However, there have been few studies in which humans have been exposed to known amounts of VOC under carefully controlled conditions. In the study 14 subjects have been exposed to a mixture of VOC (25 mg/cu m total hydrocarbon) representative of what is found in new homes and office buildings. Since irritation of the nose and throat are symptoms often associated with the upper respiratory tract and may result from an inflammatory response in the upper airways, the authors have used nasal lavage to monitor neutrophil (PMN) influx into the nasal passages following exposure to VOC. The authors report statistically significant increases in PMNs both immediately after a four hour exposure to VOC, as well as 18 hours later.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
- OSTI ID:
- 6524130
- Report Number(s):
- PB-93-181089/XAB; EPA--600/J-93/120
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANATOMY
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
BUILDINGS
COMMERCIAL BUILDINGS
CONSTRUCTION
DATA
FACE
FATIGUE
HEAD
HOUSES
INDOOR AIR POLLUTION
INFLAMMATION
INFORMATION
LAVAGE
LEUKOCYTES
MATERIALS
MECHANICAL PROPERTIES
NEUTROPHILS
NOSE
NUMERICAL DATA
OFFICE BUILDINGS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTANTS
POLLUTION
RESIDENTIAL BUILDINGS
RESPIRATORY SYSTEM
STATISTICAL DATA
SYMPTOMS
SYNTHETIC MATERIALS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANATOMY
AROMATICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
BUILDINGS
COMMERCIAL BUILDINGS
CONSTRUCTION
DATA
FACE
FATIGUE
HEAD
HOUSES
INDOOR AIR POLLUTION
INFLAMMATION
INFORMATION
LAVAGE
LEUKOCYTES
MATERIALS
MECHANICAL PROPERTIES
NEUTROPHILS
NOSE
NUMERICAL DATA
OFFICE BUILDINGS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTANTS
POLLUTION
RESIDENTIAL BUILDINGS
RESPIRATORY SYSTEM
STATISTICAL DATA
SYMPTOMS
SYNTHETIC MATERIALS