Medulloblastoma--prognostic factors and outcome of treatment: Review of the Mayo Clinic experience

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Mayo Clinic, Proceedings; (USA)

DOI:https://doi.org/10.1016/S0025-6196(12)62720-7· OSTI ID:6523138

Garton, G R; Schomberg, P J; Scheithauer, B W; Shaw, E G; Ilstrup, D M; Blackwell, C R; Laws, Jr, E R; Earle, J D ^[1]

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1. Mayo Clinic, Rochester, MN (USA)

From March 1965 through December 1984, 58 patients (35 male and 23 female patients; median age, 17 years) with posterior fossa (PF) medulloblastoma underwent surgical treatment and postoperative radiation therapy at our institution. Radiation fields were the craniospinal axis in 39 patients, PF plus spinal axis in 12, PF in 6, and whole brain in 1. Median radiation doses were 43 Gy (22 to 60 Gy) to the PF and 34 Gy (6.2 to 50 Gy) to the spinal axis. Overall 5- and 10-year survivals were 50% and 33%, respectively; 5- and 10-year relapse-free survivals were 46% and 32%. Treatment failed in 34 patients (59%): in 18 who had irradiation to the craniospinal axis (13 had received 50 Gy or less to the PF) and in 16 who had a radiation field of less than the craniospinal axis. A statistically significant (P less than 0.05) improvement in 10-year survival was associated with the following prognostic variables: PF dose of 50 Gy or more, whole-brain irradiation, and spinal axis irradiation. In comparison with subtotal resection, total resection was correlated with better 10-year relapse-free survival but not overall survival. All five patients with initial treatment failure only in the spine had received a radiation dose of 30 Gy or less to the spinal axis. The 2-year survival after relapse was 46% with salvage chemotherapy or irradiation in 23 patients and 0% in the 11 patients who received no further treatment (P less than 0.01).

• OSTI ID: 6523138
• Journal Information: Mayo Clinic, Proceedings; (USA), Journal Name: Mayo Clinic, Proceedings; (USA) Vol. 65:8; ISSN MACPA; ISSN 0025-6196
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
SURGERY
SURVIVAL CURVES
THERAPY