Soman- or kainic acid-induced convulsions decrease muscarinic receptors but not benzodiazepine receptors
Journal Article
·
· Neurotoxicology (Park Forest South, Illinois); (USA)
OSTI ID:6522653
- Univ. of Kansas Medical Center, Kansas City (USA)
(3H)Quinuclidinyl benzilate (QNB) binding to muscarinic receptors decreased in the rat forebrain after convulsions induced by a single dose of either soman, a potent inhibitor of acetylcholinesterase, or kainic acid, an excitotoxin. A Rosenthal plot revealed that the receptors decreased in number rather than affinity. When the soman-induced convulsions were blocked, the decrease in muscarinic receptors at 3 days was less extensive than when convulsions occurred and at 10 days they approached control levels in most of the brain areas. The most prominent decrements in QNB binding were in the piriform cortex where the decline in QNB binding is probably related to the extensive convulsion-associated neuropathology. The decrements in QNB binding after convulsions suggest that the convulsive state leads to a down-regulation of muscarinic receptors in some brain areas. In contrast to the decrease in QNB binding after convulsions, (3H)flunitrazepam binding to benzodiazepine receptors did not change even in the piriform cortex where the loss in muscarinic receptors was most prominent. Thus, it appears that those neuronal processes that bear muscarinic receptors are more vulnerable to convulsion-induced change than those with benzodiazepine receptors.
- OSTI ID:
- 6522653
- Journal Information:
- Neurotoxicology (Park Forest South, Illinois); (USA), Journal Name: Neurotoxicology (Park Forest South, Illinois); (USA) Vol. 11:1; ISSN 0161-813X; ISSN NRTXD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
CARBOXYLESTERASES
CHOLINE
CHOLINESTERASE
DISEASES
DRUGS
ENZYME INHIBITORS
ENZYMES
ESTERASES
HYDROGEN COMPOUNDS
HYDROLASES
HYDROXY COMPOUNDS
INHIBITION
KINETICS
LIPOTROPIC FACTORS
MAMMALS
MEMBRANE PROTEINS
NERVE CELLS
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
PARASYMPATHOMIMETICS
PATHOGENESIS
PROTEINS
QUATERNARY COMPOUNDS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SOMATIC CELLS
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
AMINES
AMMONIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
CARBOXYLESTERASES
CHOLINE
CHOLINESTERASE
DISEASES
DRUGS
ENZYME INHIBITORS
ENZYMES
ESTERASES
HYDROGEN COMPOUNDS
HYDROLASES
HYDROXY COMPOUNDS
INHIBITION
KINETICS
LIPOTROPIC FACTORS
MAMMALS
MEMBRANE PROTEINS
NERVE CELLS
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
PARASYMPATHOMIMETICS
PATHOGENESIS
PROTEINS
QUATERNARY COMPOUNDS
RATS
REACTION KINETICS
RECEPTORS
RODENTS
SOMATIC CELLS
TRITIUM COMPOUNDS
VERTEBRATES