[sup 222]Rn dosimetry in the dog lung

Conference · Tue Jan 01 04:00:00 EST 1991

OSTI ID:6522531

Harley, N H; Meyers, O A; Robbins, E S

The alpha dose to cells in bronchial airways in the beagle dog during historical exposures to [sup 222]Rn decay products is calculated using updated information on airway morphometry, call nucleus depth, mucus thickness, physical dosimetry and atmospheric characteristics. The alpha dose per unit exposure to basal call nuclei in the upper airways ranges from 2 to 7 mGy WLM[sup [minus]1] (excluding the trachea) depending upon the exposure protocol used. The dose to alveolar tissue is 3 mGy WLM[sup [minus]1]. In the human lung, the dose factor for the bronchial airways is 9 mGy WLM[sub [minus]1] and for the pulmonary parenchyma 0.5 mGy WLM[sup [minus]1] The human tumors appear primarily in the first few branching airway generations while the only tumors observed in the animals were in the bronchioloalveolar region suggesting a difference in cell sensitivity to alpha radiation.

• Research Organization: New York Univ., NY (United States). School of Medicine
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60547
• OSTI ID: 6522531
• Report Number(s): CONF-910905-5; ON: DE93014035
• Country of Publication: United States
• Language: English

Related Subjects

560101* -- Biomedical Sciences
Applied Studies-- Radiation Effects-- Dosimetry & Monitoring-- (1992-)
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
61 RADIATION PROTECTION AND DOSIMETRY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALPHA DECAY RADIOISOTOPES
ALPHA DOSIMETRY
ANIMAL CELLS
ANIMALS
BODY
BRONCHI
DAUGHTER PRODUCTS
DAYS LIVING RADIOISOTOPES
DOGS
DOSES
DOSIMETRY
EVEN-EVEN NUCLEI
HEAVY NUCLEI
ISOTOPES
LUNGS
MAMMALS
NUCLEI
ORGANS
RADIATION DOSES
RADIOISOTOPES
RADON 222
RADON ISOTOPES
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
VERTEBRATES