Promoting effect of basic lead acetate administration on the tumorigenesis of lung in N-nitrosodimethylamine-treated mice
- Chiba Univ. (Japan)
Lead compounds are frequent environmental contaminations and some of them have been found to be carcinogenic for animals, although epidemiological studies have not been considered to provide sufficient evidence that exposure to lead or lead compounds causes cancer in humans. There re only a few reports on the promoting effect of lead on chemical carcinogenesis in vivo. By the concurrent administration of lead compounds and certain organic carcinogens to rats or hamsters, the cocarcinogenic activity of lead has been found in the kidney of rats or the lung of hamsters. In this report the promoting effect of posttreatment with basic lead acetate (BLA) on the development of lung tumors in strain dd mice exposed to N-nitrosodimethylamine (NDMA) was examined. The concentration of lead and the activity of {gamma}-glutamyltranspeptidase ({gamma}-GTP) in the lung during the carcinogenicity experiment were also measured.
- OSTI ID:
- 6521540
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 44:5; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LEAD COMPOUNDS
BIOLOGICAL EFFECTS
LUNGS
CARCINOGENESIS
NITROSO COMPOUNDS
ABSORPTION SPECTROSCOPY
ACETATES
MICE
SPECTROPHOTOMETRY
TUMOR PROMOTERS
ANIMALS
BODY
CARBOXYLIC ACID SALTS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RESPIRATORY SYSTEM
RODENTS
SPECTROSCOPY
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology