Radiation-induced interphase death observed in human T-cell lymphoma cells established as a nude mouse tumor line

Journal Article · Wed Aug 01 04:00:00 EDT 1990 · Experimental Hematology (Lawrence, Kansas); (USA)

OSTI ID:6521364

Igarashi, T; Yoshida, S; Miyamoto, T ^[1]

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1. Univ. of Chiba School of Medicine (Japan)

Interphase death of cells occurs physiologically in healthy animal tissues as well as in tissues pathologically injured by radiation or drugs. An active self-destruction process has been found to play a major role in the interphase death of highly radiosensitive cells. However, the mechanism of this radiation-induced interphase death in human lymphoma has not yet been studied in detail. In the present study, we examined a lymphoma derived from a child lymphoblastic lymphoma bearing CD1, CD4, and CD8 antigens and established in nude mice. Low-dose x-irradiation of this lymphoma induced interphase cell death with characteristic morphological and biological changes of an active self-destruction process, i.e., changes in cell surface appearance seen using scanning electron microscopy and nuclear fragmentation accompanied with an increase in free DNA. The process was proved to require protein synthesis. It was concluded that the radiosensitivity of this T-cell lymphoma of common thymic type is mainly due to the occurrence of the active self-destruction process.

• OSTI ID: 6521364
• Journal Information: Experimental Hematology (Lawrence, Kansas); (USA), Journal Name: Experimental Hematology (Lawrence, Kansas); (USA) Vol. 18:7; ISSN EXHMA; ISSN 0301-472X
• Country of Publication: United States
• Language: English

Related Subjects

560120* -- Radiation Effects on Biochemicals
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
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BODY FLUIDS
CELL CYCLE
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CONNECTIVE TISSUE CELLS
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LEUKOCYTES
LOW DOSE IRRADIATION
LYMPHATIC SYSTEM
LYMPHOCYTES
LYMPHOMAS
MAMMALS
MAN
MATERIALS
MICE
MICROSCOPY
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIATIONS
RADIOSENSITIVITY
RODENTS
SCANNING ELECTRON MICROSCOPY
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