Radiation-induced interphase death observed in human T-cell lymphoma cells established as a nude mouse tumor line
- Univ. of Chiba School of Medicine (Japan)
Interphase death of cells occurs physiologically in healthy animal tissues as well as in tissues pathologically injured by radiation or drugs. An active self-destruction process has been found to play a major role in the interphase death of highly radiosensitive cells. However, the mechanism of this radiation-induced interphase death in human lymphoma has not yet been studied in detail. In the present study, we examined a lymphoma derived from a child lymphoblastic lymphoma bearing CD1, CD4, and CD8 antigens and established in nude mice. Low-dose x-irradiation of this lymphoma induced interphase cell death with characteristic morphological and biological changes of an active self-destruction process, i.e., changes in cell surface appearance seen using scanning electron microscopy and nuclear fragmentation accompanied with an increase in free DNA. The process was proved to require protein synthesis. It was concluded that the radiosensitivity of this T-cell lymphoma of common thymic type is mainly due to the occurrence of the active self-destruction process.
- OSTI ID:
- 6521364
- Journal Information:
- Experimental Hematology (Lawrence, Kansas); (USA), Vol. 18:7; ISSN 0301-472X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
TUMOR CELLS
RADIOSENSITIVITY
CELL CYCLE
CELL FLOW SYSTEMS
DNA
EXPERIMENTAL NEOPLASMS
LOW DOSE IRRADIATION
LYMPHOCYTES
LYMPHOMAS
MAN
MICE
SCANNING ELECTRON MICROSCOPY
THYMUS
X RADIATION
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
IMMUNE SYSTEM DISEASES
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
MICROSCOPY
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture