Use of zinc protoporphyrin in screening individuals for exposure to lead

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Clinical Chemistry (Winston-Salem, North Carolina); (USA)

OSTI ID:6521053

Zwennis, W C; Franssen, A C; Wijnans, M J ^[1]

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1. TNO Medical Biological Laboratory, Rijswijk (Netherlands)

We studied the relation between the concentrations of lead in blood (PbB) and zinc protoporphyrin in blood (ZPP) in a group of 801 men occupationally exposed for more than one year to lead or inorganic lead compounds. Linear regression of PbB on log ZPP provided 95% tolerance intervals for PbB values for a given ZPP value. The intervals we found are too large to warrant the estimation of PbB on the basis of ZPP measurements in health surveillance of lead workers. Instead we propose a procedure in which ZPP can be used as an indicator to decide which individuals exposed to lead need further investigation of PbB in light of existing limit values for PbB. The procedure is applicable only for PbB values of 2.4 mumol/L or more but may reduce considerably the costs for screening individuals or groups of people exposed to lead.

• OSTI ID: 6521053
• Journal Information: Clinical Chemistry (Winston-Salem, North Carolina); (USA), Journal Name: Clinical Chemistry (Winston-Salem, North Carolina); (USA) Vol. 36:8 Pt 1; ISSN 0009-9147; ISSN CLCHA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL INDICATORS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
ELEMENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LEAD
MATERIALS
METABOLISM
METALS
OCCUPATIONAL EXPOSURE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PERSONNEL
PORPHYRINS
RISK ASSESSMENT
SYNTHESIS
ZINC