Chromosomal aberrations suggestive of mutagen-related leukemia after 21 years of therapeutic radon exposure

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Cancer Genetics and Cytogenetics; (USA)

DOI:https://doi.org/10.1016/0165-4608(90)90225-Y· OSTI ID:6520294

Rechavi, G; Berkowicz, M; Rosner, E; Neuman, Y; Ben-Bassat, I; Ramot, B ^[1]

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1. Tel-Aviv Univ. (Israel)

A 68-year-old woman with acute myelomonocytic leukemia, who was treated annually for 21 consecutive years by therapeutic low-dose radon gas radiation because of spondyloarthritis, is described. The karyotype of the malignant clone was 45,XX, -17, -18,del(5)(q15q33), +t(17;18)(q11.2q23). In 45% of the metaphases, the modal number was between hyperdiploid to near tetraploid. Double minute chromosomes were demonstrated in 60% of the cells. These chromosomal aberrations are suggestive of mutagen-related leukemia.

• OSTI ID: 6520294
• Journal Information: Cancer Genetics and Cytogenetics; (USA), Vol. 48:1; ISSN 0165-4608
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
MYELOID LEUKEMIA
RADON
MUTAGENESIS
SPONDYLITIS
RADIOTHERAPY
DELAYED RADIATION EFFECTS
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MUTATIONS
NEOPLASMS
NONMETALS
NUCLEAR MEDICINE
RADIATION EFFECTS
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560161* - Radionuclide Effects
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