Synthesis of C-11 iodoantipyrine for positron emission tomography. [Rats]

Conference · Mon Jun 01 04:00:00 EDT 1981 · J. Nucl. Med.; (United States)

OSTI ID:6519976

Campbell, J A; Finn, R D; Boothe, R E; Djermouni, B; Ginsberg, M D; Lockwood, A H; Gilson, A J; Ache, H J

A method for the synthesis of C-11 iodoantipyrine was developed. Carbon-11-labeled methyl iodide, prepared from /sup 11/CO/sub 2/, was used to methylate 3-methyl-1-phenyl-2-pyrazolin-5-one to form C-11 antipyrine. Preliminary animal studies showed complete cerebral extraction and local cerebral blood-flow values that were within 4.6% of those obtained using C-14 iodoantipyrine. The C-11 analog, with positron emission tomography, will facilitate local cerebral blood-flow studies in human subjects.

• Research Organization: Mount Sinai Medical Center, Miami Beach, FL
• OSTI ID: 6519976
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 22:6
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHEMICAL PREPARATION
CHEMICAL REACTIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HALOGENATION
HETEROCYCLIC COMPOUNDS
IODINATION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PYRAZOLES
PYRAZOLINES
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SYNTHESIS
TOMOGRAPHY
VERTEBRATES