Interaction of 7,10-dimethylbenz(c)acridine with deoxyribonucleic acid

Journal Article · Sun Oct 01 04:00:00 EDT 1989 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01701931· OSTI ID:6519727

Kamata, Kunihiro ^[1]; Motohashi, Noboru ^[2]

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1. Metropolitan Research Laboratory of Public Health, Tokyo (Japan)
2. Meiji College of Pharmacy, Tokyo (Japan)

Many aza-heterocyclic hydrocarbons (aza-arenes) including 7,10-dimethylbenz(c)acridine (BAc) are potentially hazardous environmental contaminants because of their carcinogenic and mutagenic character. The recent synthesis of a large number of potential metabolites of benz(c)acridine has permitted an analysis of the mutagenic activity of these compounds in bacterial and mammalian cells, and mouse skin. These results provided initial evidence for bay-region activation of benz(c)acridine to ultimate mutagenic and carcinogenic metabolites. Apart from some structure-activity relationships on BAc, little work has been done with BAc in vitro. Researchers have shown the interaction of BAc and deoxyribonucleic acid (DNA) by using ultraviolet measurement. The double-helical structure of DNA has appeared to play an essential role in the interaction. There was a corresponding correlation among the electron spin resonance (ESR) signal intensity of the free radical formed in a system of BAc and protein, charge of the K-region or ring nitrogen of Bac. The present study is aimed at understanding the mechanisms of the interaction of BAc with DNA in vitro by measuring the fluorescence and viscosity.

• OSTI ID: 6519727
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 43:4; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRIDINES
AROMATICS
AZAARENES
AZINES
CHEMICAL REACTIONS
CROSS-LINKING
DNA
EMISSION SPECTRA
EMISSION SPECTROSCOPY
FLUORESCENCE SPECTROSCOPY
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PH VALUE
POLYCYCLIC AROMATIC HYDROCARBONS
POLYMERIZATION
PYRIDINES
SPECTRA
SPECTROSCOPY
VISCOSITY