Accumulation, metabolism and toxicity of parathion in tadpoles
- Fish and Wildlife Service, Laurel, MD (USA)
Earlier work exposing tadpoles to organophosphorus pesticides indicated the great resistance of tadpoles of the bullfrog (Rana catesbeiana) to these chemicals and their surprising ability to accumulate parathion and fenthion from water. These qualities seemed to make them an ideal model with which to test a hypothesis advanced by Burke and Ferguson, who noted that parathion is more toxic to resistant mosquitofish in static water than in flowing water--a reversal of the pattern normally seen. They believed that highly toxic metabolite paraoxon was produced by the fish and that its buildup in static systems resulted in the unexpected mortality. Amphibians have been shown to produce paraoxon and to accumulate the parent compound parathion to levels that are potentially hazardous to other organisms. In the course of examining paraoxon production by tadpoles, it would also be possible to learn more about their patterns of parathion uptake and elimination. Retention of residues is also a matter of concern given the high levels observed in the earlier studies.
- OSTI ID:
- 6519283
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (USA), Vol. 44:4; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC PHOSPHORUS COMPOUNDS
TOXICITY
PARATHION
METABOLISM
BIOLOGICAL ACCUMULATION
FLAME PHOTOMETRY
FROGS
GAS CHROMATOGRAPHY
WATER POLLUTION
AMPHIBIANS
ANIMALS
AQUATIC ORGANISMS
CHROMATOGRAPHY
ESTERS
INSECTICIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PESTICIDES
PHOTOMETRY
POLLUTION
SEPARATION PROCESSES
THIOPHOSPHORIC ACID ESTERS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology