Human urinary excretion profile after smoking and oral administration of ( sup 14 C)delta 1-tetrahydrocannabinol

Journal Article · Tue May 01 00:00:00 EDT 1990 · Journal of Analytical Toxicology; (USA)

DOI:https://doi.org/10.1093/jat/14.3.176· OSTI ID:6519151

Johansson, E; Gillespie, H K; Halldin, M M ^[1]

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1. BMC, Uppsala (Sweden)

The urinary excretion profiles of delta 1-tetrahydrocannabinol (delta 1-THC) metabolites have been evaluated in two chronic and two naive marijuana users after smoking and oral administration of ({sup 14}C)delta 1-THC. Urine was collected for five days after each administration route and analyzed for total delta 1-THC metabolites by radioactivity determination, for delta 1-THC-7-oic acid by high-performance liquid chromatography, and for cross-reacting cannabinoids by the EMIT d.a.u. cannabinoid assay. The average urinary excretion half-life of {sup 14}C-labeled delta 1-THC metabolites was calculated to be 18.2 +/- 4.9 h (+/- SD). The excretion profiles of delta 1-THC-7-oic acid and EMIT readings were similar to the excretion profile of {sup 14}C-labeled metabolites in the naive users. However, in the chronic users the excretion profiles of delta 1-THC-7-oic acid and EMIT readings did not resemble the radioactive excretion due to the heavy influence from previous Cannabis use. Between 8-14% of the radioactive dose was recovered in the urine in both user groups after oral administration. Lower urinary recovery was obtained both in the chronic and naive users after smoking--5 and 2%, respectively.

• OSTI ID: 6519151
• Journal Information: Journal of Analytical Toxicology; (USA), Journal Name: Journal of Analytical Toxicology; (USA) Vol. 14:3; ISSN 0146-4760; ISSN JATOD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CHROMATOGRAPHY
CLEARANCE
EXCRETION
HERBS
INHALATION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIQUID COLUMN CHROMATOGRAPHY
MAGNOLIOPHYTA
MAGNOLIOPSIDA
MARIHUANA
MATERIALS
METABOLISM
METABOLITES
ORAL ADMINISTRATION
PLANTS
SEPARATION PROCESSES
TRACER TECHNIQUES
URINE
WASTES