Use of second antibody in radioimmunotherapy

Journal Article · Thu Jan 01 04:00:00 EST 1987 · NCI Monogr.; (United States)

OSTI ID:6518729

Begent, R H; Bagshawe, K D; Pedley, R B; Searle, F; Ledermann, J A; Green, A J; Keep, P A; Chester, K A; Glaser, M G; Dale, R G

In this study, a second antibody was directed against the first antitumor antibody to accelerate clearance of the /sup 131/I-labeled first antibody and improve tumor to normal tissue ratios of radioactivity. The value of this method in improving the therapeutic index of radioimmunotherapy with /sup 131/I-antibody to CEA has been investigated in nude mice bearing xenografts of human colon carcinoma and in 5 patients with colorectal cancer. The xenografts did not become saturated with anti-CEA as the administered dose was increased to therapeutic levels. At these high dose levels, the second antibody increased tumor to blood ratios to a maximum of 155:1, 48 times the level in controls that did not receive the second antibody. In 5 patients given 50 mCi of anti-CEA, there was no significant toxicity with the second antibody; clearance of radioactivity was accelerated; and tumor imaging was enhanced. The second antibody appears to have the potential to improve the therapeutic index of radioimmunotherapy.

• Research Organization: Charing Cross and Westminster Medical School, London, England
• OSTI ID: 6518729
• Journal Information: NCI Monogr.; (United States), Journal Name: NCI Monogr.; (United States) Vol. 3; ISSN NCIME
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CARCINOEMBRYONIC ANTIGEN
CARCINOMAS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
GASTROINTESTINAL TRACT
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
INTESTINES
IODINE 131
IODINE ISOTOPES
ISOTOPES
LARGE INTESTINE
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPEUTIC USES
THERAPY
TOXICITY
TRANSPLANTS
USES
VERTEBRATES