Cadium-induced bone loss: Effects in ovariectomized mice and osteoclast-like cells in culture
The research reported here was conducted to investigate the possibility that cadmium might be a factor that increases bone loss after the menopause. In our first study, we exposed female CF1 mice to a purified diet containing CdCl2 at either 0.25, 5.0, or 50 ppM Cd starting at 70 days of age. After 12 months of exposure, mice were ovariectomized (OV) or sham-operated (SO). After surgery, they remained on their respective diets for an additional six months before sacrifice. Results showed that neither ovariectomy alone nor dietary Cd exposure alone significantly decrease bone calcium content. However, dietary Cd at 50 ppM in combination with ovariectomy caused a striking decrease in the calcium content of mouse bones. The mice in the above study were quite old (435 days old at ovariectomy; 617 days old at sacrifice) and had been exposed to dietary cadmium for one year prior to removal of the ovaries. Consequently, the follow-up study reported here was conducted in mice whose skeletons were pre-labelled with UVCa. This study was designed to determine whether cadmium exposure would cause as increased release of UVCa from the skeletons of OV mice immediately after the start of cadmium exposure and in the absence of the one-year pre-exposure period present in our first study. Such results would indicate that cadmium might act directly on bone rather than indirectly by way of damage to another organ such as the kidney. 14 refs., 1 fig.
- Research Organization:
- Argonne National Lab., IL (USA)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 6517621
- Report Number(s):
- CONF-8811145-1; ON: DE89004264
- Resource Relation:
- Conference: U.S. Department of Energy/Office of Health and Environmental Research contractors meeting on chemical toxicology, Albuquerque, NM, USA, 17 Nov 1988; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
Similar Records
Osteoporotic-like effects of cadmium on bone mineral density and content in aged ovariectomized beagles
Female reproduction and pup survival and growth for mice fed a cadmium-containing purified diet through six consecutive rounds of gestation and lactation
Related Subjects
BONE CELLS
MODIFICATIONS
CADMIUM COMPOUNDS
BIOLOGICAL EFFECTS
BONE FRACTURES
CALCIUM 45
CALCIUM COMPOUNDS
HORMONES
NUTRITIONAL DEFICIENCY
OVARIES
RESPONSE MODIFYING FACTORS
TRACER TECHNIQUES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CALCIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
EVEN-ODD NUCLEI
FEMALE GENITALS
GONADS
INJURIES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ORGANS
RADIOISOTOPES
SOMATIC CELLS
550501* - Metabolism- Tracer Techniques
551000 - Physiological Systems