Administration of MPTP to the common marmoset does not alter cortical cholinergic function

Journal Article · Wed Jan 01 04:00:00 EST 1986 · Mov. Disord.; (United States)

DOI:https://doi.org/10.1002/mds.870010207· OSTI ID:6515589

Garvey, J; Petersen, M; Waters, C M; Rose, S P; Hunt, S; Briggs, R; Jenner, P; Marsden, C D

The administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to common marmosets induced persistent motor deficits and decreased concentrations of dopamine, homovanillic acid, and 3,4-dihydroxy-phenylacetic acid (DOPAC) and (TH)dopamine uptake in the caudate-putamen. There was an 80% reduction in tyrosine hydroxylase immunoreactive cells in substantia nigra. At 10 days following the start of MPTP administration, the activity of choline acetyltransferase in the thalamus and frontal cortex was unchanged compared with control animals. Similarly, specific (TH)QNB binding was unaltered. At 4-6 weeks following the start of MPTP treatment, choline acetyltransferase activity and (TH)QNB binding in the frontal cortex and thalamus remained unaffected. There was no evidence for cell loss in the nucleus basalis of Meynert or alteration in the intensity of staining for acetylcholinesterase. MPTP treatment of the common marmoset produces a nigrostriatal lesion. In contrast, MPTP did not alter cortical cholinergic function and was not neurotoxic to the cholinergic cells in the nucleus basalis of Meynert.

• Research Organization: Univ. Department of Neurology, London (England)
• OSTI ID: 6515589
• Journal Information: Mov. Disord.; (United States), Journal Name: Mov. Disord.; (United States) Vol. 1:2; ISSN MOVDE
• Country of Publication: United States
• Language: English

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550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DISEASES
DOPAMINE
DRUGS
ENZYME ACTIVITY
ENZYMES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
MONKEYS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PRIMATES
PROTEINS
PYRIDINES
REACTION KINETICS
RECEPTORS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRANSFERASES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES