Thiamine absorption is not compromised in folate-deficient rats
Journal Article
·
· J. Nutr.; (United States)
OSTI ID:6515259
Thiamine absorption and excretion were assessed in rats with severe folate deficiency (FD) by determining the fate of oral TH-labeled and intravenous UC-labeled thiamine over a 6-h test period. Thiamine status was evaluated in these same rats by measuring transketolase activity levels of blood before (TKA) and after (TPPE) addition of thiamine pyrophosphate to the incubation mixture of the assay procedure. Two additional experiments assessed active transport of thiamine and the effect of dietary succinylsulfathiazole (SST) on TKA and TPPE in rats with moderate FD. Intestinal absorption in general and thiamine absorption in particular and thiamine status were unaltered in rats with severe FD. Inanition associated with severe FD may impair thiamine status. Thiamine absorption by active transport was not compromised in FD, and dietary succinylsulfathiazole did not affect thiamine status.
- Research Organization:
- Univ. of California, Davis (USA)
- OSTI ID:
- 6515259
- Journal Information:
- J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 118:11; ISSN JONUA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
AZINES
AZOLES
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ENZYME ACTIVITY
ENZYMES
FOLIC ACID
GLANDS
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
NUTRITIONAL DEFICIENCY
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PTERIDINES
PYRIMIDINES
RATS
RODENTS
THIAMINE
THIAZOLES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSFERASES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
AZINES
AZOLES
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ENZYME ACTIVITY
ENZYMES
FOLIC ACID
GLANDS
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTESTINAL ABSORPTION
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
NUTRITIONAL DEFICIENCY
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PTERIDINES
PYRIMIDINES
RATS
RODENTS
THIAMINE
THIAZOLES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRANSFERASES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS