Molecular loci for potential drug toxicity in ovaries
Journal Article
·
· Environ. Health Perspect.; (United States)
Ovarian follicular development is dependent on the actions and interactions of the pituitary gonadotropins, FSH and LH, and the ovarian steroid hormone, estradiol. Agents which might block the effects of these hormones would increase follicular atresia and reduce fertility. In addition, any substance toxic to the oocyte and its normal pattern of growth and meiosis would lead to reduced numbers of oocytes and follicles and impaired fertility. Autoimmune diseases may be one major causes of premature ovarian failure, and such diseases might be triggered by toxic external stimuli.
- Research Organization:
- Baylor College of Medicine, Houston, TX
- OSTI ID:
- 6515061
- Journal Information:
- Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 70; ISSN EVHPA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMISTRY
BODY
CELL DIFFERENTIATION
CHEMISTRY
DRUGS
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
FSH
GONADOTROPINS
GONADS
HORMONES
HYDROXY COMPOUNDS
LH
ORGANIC COMPOUNDS
ORGANS
OVARIES
PEPTIDE HORMONES
PITUITARY HORMONES
REPRODUCTION
STEROID HORMONES
STEROIDS
TOXICITY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMISTRY
BODY
CELL DIFFERENTIATION
CHEMISTRY
DRUGS
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
FSH
GONADOTROPINS
GONADS
HORMONES
HYDROXY COMPOUNDS
LH
ORGANIC COMPOUNDS
ORGANS
OVARIES
PEPTIDE HORMONES
PITUITARY HORMONES
REPRODUCTION
STEROID HORMONES
STEROIDS
TOXICITY