Aquatic versus mammalian toxicology: applications of the comparative approach

Journal Article · Wed Apr 01 00:00:00 EST 1987 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.877117· OSTI ID:6514299

Guarino, A M

The large body of literature and techniques generated by mammalian toxicity studies provides a conceptual and technical framework within which the absorption, fate, and disposition of xenobiotics in aquatic organisms can be studied. This review emphasizes the similarities and differences between mammalian and aquatic systems, e.g., lung vs. gill as site of absorption and toxicity. These must be taken into consideration when designing aquatic toxicity studies. Studies of phenol red in dogfish shark as an example show physiologic-based pharmacokinetic modeling to be a useful tool for investigating and eventually predicting species differences in xenobiotic disposition and drug differences within the same species. This discussion demonstrates that both laboratory and modeling procedures are now available to carry out sophisticated studies of xenobiotic fate and disposition in fish. Such studies are needed to pinpoint sites and mechanisms of pollutant toxicity in aquatic organisms.

• Research Organization: Food and Drug Administration, Dauphin Island, AL
• OSTI ID: 6514299
• Journal Information: Environ. Health Perspect.; (United States), Vol. 71
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PHENOLS
PHARMACOLOGY
TISSUE DISTRIBUTION
WATER POLLUTION
TOXICITY
ABSORPTION
BILE
BIOLOGICAL MODELS
COMPARTMENTS
FISHES
GILLS
LUNGS
MAMMALS
URINE
ANIMALS
AQUATIC ORGANISMS
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BIOLOGICAL WASTES
BODY
BODY FLUIDS
DISTRIBUTION
HYDROXY COMPOUNDS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
POLLUTION
RESPIRATORY SYSTEM
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology