Radiation absorbed dose estimates for oxygen-15 radiopharmaceuticals (H2( V)O, C VO, O VO) in newborn infants

Journal Article · Thu Dec 01 04:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:6514224

Powers, W J; Stabin, M; Howse, D; Eichling, J O; Herscovitch, P

In preparation for measurement of regional cerebral oxygen metabolism by positron emission tomography, radiation absorbed dose estimates for 19 internal organs, blood, and total body were calculated for newborn infants following bolus intravenous administration of H2( V)O and brief inhalation of C VO and O VO. Cumulated activity for each radiopharmaceutical was calculated from a compartmental model based on the known biologic behavior of the compound. Values for mean absorbed dose/unit cumulated activity (S) for internal organs and total body were based on a newborn phantom. S was separately calculated for blood. Total radiopharmaceutical absorbed dose estimates necessary to measure cerebral oxygen metabolism in a 3.51-kg infant based on 0.7 mCi/kg H2( V)O and 1 mCi/kg C VO and O VO were determined to be 1.6 rad to the lung (maximum organ dose), 0.28 rad to the marrow, 0.46 rad to the gonads, and 0.22 rad to total body. These values are similar to those for current clinical nuclear medicine procedures employing /sup 99m/Tc in newborn infants.

• Research Organization: Mallinckrodt Institute of Radiology, St. Louis, MO (USA)
• OSTI ID: 6514224
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

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AGE GROUPS
BETA DECAY RADIOISOTOPES
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BODY
BRAIN
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
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CHALCOGENIDES
CHILDREN
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
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DRUGS
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EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
INFANTS
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MINUTES LIVING RADIOISOTOPES
MOCKUP
NERVOUS SYSTEM
NONMETALS
NUCLEI
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OXIDES
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OXYGEN 15
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PHANTOMS
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
RADIOISOTOPES
RADIOPHARMACEUTICALS
STRUCTURAL MODELS
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