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Use of scintigraphy in the quantitation of myocardial infarction. Final scientific report 30 June 1975--30 June 1977

Technical Report ·
OSTI ID:6510686
;
In these studies the possibility was examined that myocardial scintigraphy could be used to quantitate infarct size. Thallium-201 and technetium-99m pyrophosphate were the isotopes which were utilized. Tissue models of autoradiographic distribution of the two isotopes were established. It was shown that the myocardial distribution of both isotopes correlated well with indices of tissue damage. Computer methods were used to quantitate thallium-201 scintigrams and it was shown that scintigraphic estimates of infarct size correlate well with the volume of infarcted tissue determined from tissue studies. Similar correlative studies with technetium-99m remain incomplete. It was further shown that thallium-201 can be extruded from an infarcted area. Studies with both isotopes indicate they provide similar data on infarct size. Methods were established to study the mechanism of technetium-99m uptake in damaged cells in tissue culture. Finally, preliminary scintigraphic data was obtained from patients with acute myocardial infarction.
Research Organization:
Medical Coll. of Ohio, Toledo (USA)
OSTI ID:
6510686
Report Number(s):
PB-280056
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MYOCARDIAL INFARCTION
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
YEARS LIVING RADIOISOTOPES