Imaging of acute myocardial infarction in pigs with Indium-111 monoclonal antimyosin scintigraphy and MRI

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Investigative Radiology; (USA)

DOI:https://doi.org/10.1097/00004424-199007000-00010· OSTI ID:6510256

ten Kate, C I; van Kroonenburgh, M J; Schipperheyn, J J; Doornbos, J; Hoedemaeker, P J; Maes, A; v d Nat, K H; Camps, J A; Huysmans, H A; Pauwels, E K ^[1]

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1. Univ. of Leiden (Netherland)

Indium-111 antimyosin F(ab')2 was used in a series of scintigraphic studies on experimentally induced myocardial infarctions in pigs. Antimyosin distribution recorded by planar images of in vivo pigs and by single photon emission computed tomography (SPECT) of excised hearts delineated areas of myocardial necrosis if infarct volume exceeded 3.3 cm3. Scintigraphic images were compared with magnetic resonance images (MRI) obtained from excised hearts and with photographs of slices of the hearts. Infarct size and localization determined with antimyosin were compared. The MR images, with or without gadolinium-DTPA (Gd-DTPA), of the in vivo pigs were all false-negative; some myocardial wall thinning and high bloodpool signals were visible. Results show that both the antimyosin and the MR technique are specific methods for the visualization of induced myocardial necrosis in this animal model. However, the use of antimyosin is limited to a period ranging from 24 to 72 hours after infarction.

• OSTI ID: 6510256
• Journal Information: Investigative Radiology; (USA), Vol. 25:7; ISSN 0020-9996
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
IMAGE PROCESSING
MYOCARDIAL INFARCTION
DIAGNOSIS
DTPA
INDIUM 111
MONOCLONAL ANTIBODIES
NMR IMAGING
RADIOIMMUNOSCINTIGRAPHY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SWINE
AMINO ACIDS
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOMESTIC ANIMALS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SCINTISCANNING
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES
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550600 - Medicine