MRI effects on the teratogenicity of x-irradiation in the C57BL/6J mouse

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Magnetic Resonance Imaging; (USA)

DOI:https://doi.org/10.1016/0730-725X(90)90051-3· OSTI ID:6508914

Tyndall, D A ^[1]

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1. Univ. of North Carolina, Chapel Hill (USA)

This investigation was undertaken in order to ascertain the combined effects of magnetic resonance imaging (MRI) fields and x-irradiation on the developing eye of the mouse strain C57B1/6J. Dams in groups of 15 were subjected to absorbed doses of 5, 15, and 30 cGy. Other dams (N = 15) were exposed to T2 spin-echo MRI fields under clinically realistic conditions following exposure to 30 cGy of x-irradiation. The developing eye was the biological end point studied. It was found that the 30-cGy dose resulted in teratogenic significance (p less than or equal to .05) for the C57B1/6J mouse. Groups exposed to both types of radiation fields demonstrated malformation levels similar to the 30-cGy irradiated animals with no additive or synergistic effects detected. The malformation rates and degree of statistical significance varied somewhat with unit of measurement, and analytical method. The results confirmed low level X-ray teratogenicity and suggested that the MRI techniques employed for this investigation did not enhance the teratogenicity of x-irradiation on eye malformations produced in the C57B1/6J mouse.

• OSTI ID: 6508914
• Journal Information: Magnetic Resonance Imaging; (USA), Vol. 8:4; ISSN 0730-725X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CONGENITAL MALFORMATIONS
RADIOINDUCTION
EYES
BIOLOGICAL RADIATION EFFECTS
X RADIATION
TERATOGENESIS
DOSE-RESPONSE RELATIONSHIPS
MICE
NMR IMAGING
RADIATION DOSES
SYNERGISM
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DIAGNOSTIC TECHNIQUES
DOSES
ELECTROMAGNETIC RADIATION
FACE
HEAD
IONIZING RADIATIONS
MALFORMATIONS
MAMMALS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
SENSE ORGANS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals