Future directions in epidemiologic studies of 1,3-butadiene-exposed workers

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.1289/ehp.9086129· OSTI ID:6508145

Acquavella, J F ^[1]

---

1. Monsanto Company, St. Louis, MO (USA)

To date, epidemiologic research on 1,3-butadiene has consisted of cohort mortality studies of workers in the styrene-butadiene rubber (SBR) and butadiene monomer industries. These studies have been extremely useful both in defining the focus on human health effects to the lymphopoietic cancers and in providing a perspective on which to evaluate the available animal models for human risk assessment. The next step for epidemiologic research will involve a lymphopoietic cancer case control approach to enable a more precise assessment of whether there is a relationship between 1,3-butadiene exposure and lymphopoietic cancer. In addition, periodic mortality updates of the 1,3-butadiene-exposed worker cohorts will be important to monitor trends in lymphopoietic cancer rates and to ensure that other cancers with long latency do not begin to show elevated rates. This paper describes an industry-sponsored program of case-control and cohort mortality update studies along with the critical elements in research design and analysis for each study. Epidemiological studies will play an important role in testing hypotheses developed from toxicological studies about potential biological mechanisms of 1,3-butadiene carcinogenesis in humans.

• OSTI ID: 6508145
• Journal Information: Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 86; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BUTADIENE
CARCINOGENESIS
CHEMICAL INDUSTRY
DIENES
DISEASES
EPIDEMIOLOGY
HYDROCARBONS
IMMUNE SYSTEM DISEASES
INDUSTRY
LYMPHOMAS
NEOPLASMS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PATHOGENESIS
PERSONNEL
POLYENES