Biomimetic methane oxidation

Conference · Fri Jun 12 00:00:00 EDT 1992

OSTI ID:6507210

Watkins, B E; Droege, M W; Taylor, R T; Satcher, J H

Methane monooxygenase (MMO) is an enzyme found in methanotrophs that catalyses the selective oxidation of methane to methanol. MMO is protein complex one component of which is a binuclear metal center containing oxygenase. We have completed one round of a design/synthesis/evaluation cycle in the development of coordination complexes that mimic the structure/function of the MMO active site. One of these, a binuclear, coordinately-asymmetric copper complex, is capable of oxidizing cyclohexane to a mixture of cyclohexanol and cyclohexanone in the presence of hydrogen peroxide.

• Research Organization: Lawrence Livermore National Lab., CA (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6507210
• Report Number(s): UCRL-JC-110675; CONF-921152--14; ON: DE93013196
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ALCOHOLS
ALKANES
BIOMIMETIC PROCESSES
BIOTECHNOLOGY
CATALYTIC EFFECTS
CHEMICAL REACTIONS
COMPLEXES
COPPER COMPLEXES
CYCLOALKANES
CYCLOHEXANE
ENZYMES
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
HYDROXY COMPOUNDS
HYDROXYLATION
KETONES
METHANE
METHANOL
ORGANIC COMPOUNDS
OXIDATION
OXIDOREDUCTASES
OXYGEN COMPOUNDS
OXYGENASES
PEROXIDES
PROTEIN ENGINEERING
PROTEINS
SYNTHESIS
TRANSITION ELEMENT COMPLEXES