Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow. [Rabbits]

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6502702
; ; ; ; ;
The correlation between prostaglandin E (PgE) and scintigrams of bone (Tc-99m MDP) and bone marrow (Tc-99m SC) was investigated in normal and VX-2-bearing rabbits. PgE in plasma of normal rabbits was 486.2. In rabbits with VX-2 transplanted into femoral muscles, PgE was in the normal range unless the tumor invaded bone. PgE was not increase significantly in rabbits when the tumor was transplanted into the marrow cavity. When tumor invaded bone, PgE increassed markedly (to 1335). Elevation of PgE did not necessarily coincide with the appearance of positive bone scans. PgE in an indomethacin-treated group did not necessarily coincide with the appearance of positive bone scans. PgE in an indomethacin-treated group did not higher than in the untreated group. Indomethacin may suppress the local acceleration of calcium metabolism.
Research Organization:
Kawasaki Medical School, Japan
OSTI ID:
6502702
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

Similar Records

Effects of prostaglandin on experimental bone malignancy and on scintigrams of bone and marrow
Journal Article · Fri May 01 00:00:00 EDT 1981 · J. Nucl. Med.; (United States) · OSTI ID:5706641
Use of Tc-99m MDP bone scanning in the study of vascularized bone implants: concise communication. [Dogs]
Conference · Mon Jun 01 00:00:00 EDT 1981 · J. Nucl. Med.; (United States) · OSTI ID:6232507
The use of Tc-99m MDP bone scanning in the study of vascularized bone implants: concise communication
Journal Article · Mon Jun 01 00:00:00 EDT 1981 · J. Nucl. Med.; (United States) · OSTI ID:5638966

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH METALS
ANIMAL TISSUES
ANIMALS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BONE MARROW
CALCIUM
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELEMENTS
EVALUATION
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
METALS
METASTASES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROSTAGLANDINS
RABBITS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES