Chromosome damage in wild rodents inhabiting a site contaminated with Aroclor 1254
Journal Article
·
· Environmental Toxicology and Chemistry; (United States)
- Oklahoma State Univ., Stillwater (United States)
An in situ investigation of structural chromosomal damage in wild rodents from a site contaminated with Aroclor 1254 was undertaken to compare effects observed in nature to those documented in previous laboratory studies. Laboratory assays indicate that Aroclor 1254 does not cause structural damage to chromosomes. However, the many variables at work in actual waste-site environments and receptor populations led the authors to question whether exposures under natural conditions could potentially lead to different results using the same assay systems. Individuals of three rodent species, Peromyscus leucopus, Sigmodon hispidus, and Reithrodontomys fulvescens, were collected from the contaminated site and three matched, pristine reference sites. Standard somatic metaphase chromosome preparations from bone marrow were examined for chromosomes lesions. Comparisons were made between conspecifics from the Aroclor-contaminated site and the reference sites. Significant increases in chromosome damage were not observed in animals from the Aroclor-contaminated site, indicating agreement between laboratory assays and an in situ application of this assay system.
- OSTI ID:
- 6500869
- Journal Information:
- Environmental Toxicology and Chemistry; (United States), Journal Name: Environmental Toxicology and Chemistry; (United States) Vol. 12:4; ISSN ETOCDK; ISSN 0730-7268
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
BONE MARROW
CHLORINATED AROMATIC HYDROCARBONS
CHROMOSOMAL ABERRATIONS
GENETIC EFFECTS
HALOGENATED AROMATIC HYDROCARBONS
HEMATOPOIETIC SYSTEM
MAMMALS
MUTATIONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RODENTS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
BIOLOGICAL EFFECTS
BODY
BONE MARROW
CHLORINATED AROMATIC HYDROCARBONS
CHROMOSOMAL ABERRATIONS
GENETIC EFFECTS
HALOGENATED AROMATIC HYDROCARBONS
HEMATOPOIETIC SYSTEM
MAMMALS
MUTATIONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RODENTS
TISSUES
VERTEBRATES