Postmortem examination of 22 pancreatic carcinoma patients treated with helium ion irradiation

Journal Article · Wed Feb 01 00:00:00 EST 1984 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19840201)53:3<420::AID-CNCR2820530309>3.0.CO;2-D· OSTI ID:6500164

Woodruff, K H; Castro, J R; Quivey, J M; Saunders, W M; Chen, G T; Lyman, J T; Pitluck, S; Tobias, C A; Walton, R E; Peters, T C

Postmortem findings are available in this report in 22 patients with pancreatic carcinoma treated with helium ions at Lawrence Berkeley Laboratory; California. This represents the largest group evaluated histologically in the literature and is the first report evaluating effects of particle radiation in pancreatic tissue. Patient survival after therapy averaged 9 months. Most died of infection and/or pulmonary emboli. Local control was achieved in 27%. The pancreatic tumors had histologically more severe radiation changes than nontumor bearing pancreas. Irradiated bone marrow was severely hypocellular, and irradiated skin was atrophic. Five patients had radiation injury in the gastrointestinal tract. The spinal cord, liver, and kidneys showed no damage. This study demonstrates the safety of helium particle irradiation with present therapeutic planning. Injury to tumor was seen without excessive damage to adjacent tissues.

• Research Organization: Lawrence Berkeley Lab., Berkeley, CA
• OSTI ID: 6500164
• Journal Information: Cancer (Philadelphia); (United States), Vol. 53:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BONE MARROW
BIOLOGICAL RADIATION EFFECTS
GASTROINTESTINAL TRACT
RADIOTHERAPY
SIDE EFFECTS
SKIN
AUTOPSY
CARCINOMAS
PANCREAS
PATIENTS
RADIATION INJURIES
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
GLANDS
HEMATOPOIETIC SYSTEM
INJURIES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
TISSUES
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)