Glutathione depletion in tissues after administration of buthionine sulphoximine
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6500053
Buthionine sulphoximine (BSO) an inhibitor of glutathione (GSH) biosynthesis, was administered to mice in single and repeated doses. The resultant pattern of GSH depletion was studied in liver, kidney, skeletal muscle and three types of murine tumor. Liver and kidney exhibited a rapid depletion of GSH. Muscle was depleted to a similar level, but at a slower rate after a single dose. All three tumors required repeated administration of BSO over several days to obtain a similar degree of depletion to that shown in the other tissues.
- Research Organization:
- Mount Vernon Hospital, Northwood, England
- OSTI ID:
- 6500053
- Report Number(s):
- CONF-8311204-
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:8; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOSYNTHESIS
BODY
CARCINOMAS
CHEMISTRY
DIGESTIVE SYSTEM
DISEASES
DRUGS
FIBROSARCOMAS
GLANDS
GLUTATHIONE
IMINES
INHIBITION
KIDNEYS
LIVER
MAMMALS
MICE
MUSCLES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SARCOMAS
SYNTHESIS
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOSYNTHESIS
BODY
CARCINOMAS
CHEMISTRY
DIGESTIVE SYSTEM
DISEASES
DRUGS
FIBROSARCOMAS
GLANDS
GLUTATHIONE
IMINES
INHIBITION
KIDNEYS
LIVER
MAMMALS
MICE
MUSCLES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SARCOMAS
SYNTHESIS
VERTEBRATES