Effect of metal ions on the adaptive response induced by N-methyl-N-nitrosourea in Escherichia coli
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
Induction of the adaptive response was quantified by analysis of beta-galactosidase released after the treatment of Escherichia coli CHS26/pYM3 (ada'-lacZ') with N-methyl-N-nitrosourea (MNU). Of the 15 metal ions examined, only Cd++ and Hg++ inhibited induction of the adaptive response with neither severe suppression of cell growth nor inhibition of the induction of the SOS response by MNU. Mutagenicity of MNU was potentiated by the presence of these metal ions in an E. coli strain. These results suggest that the inhibition mechanism involves a specific interaction of Cd++ or Hg++ with O6-methyl-guanine-DNA methyltransferase.
- Research Organization:
- Nagoya City Univ. (Japan)
- OSTI ID:
- 6495936
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 157:3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CADMIUM
CATIONS
CHARGED PARTICLES
DNA REPAIR
ELEMENTS
ENZYMES
ESCHERICHIA COLI
GROWTH
INHIBITION
IONS
MERCURY
METALS
METHYL TRANSFERASES
MICROORGANISMS
MUTAGENESIS
NITROSO COMPOUNDS
NITROSOUREAS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RECOVERY
REPAIR
TRANSFERASES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL ADAPTATION
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CADMIUM
CATIONS
CHARGED PARTICLES
DNA REPAIR
ELEMENTS
ENZYMES
ESCHERICHIA COLI
GROWTH
INHIBITION
IONS
MERCURY
METALS
METHYL TRANSFERASES
MICROORGANISMS
MUTAGENESIS
NITROSO COMPOUNDS
NITROSOUREAS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RECOVERY
REPAIR
TRANSFERASES