Estimating the acute toxicity of narcotic industrial chemicals to fathead minnows
The overwhelming number of industrial chemicals either in commerce or in development precludes actual toxicity testing of each chemical and creates a need for initial screening techniques to focus efforts on those chemicals with the greatest potential for adverse environmental effects. One promising screening technique is the use of the structure-activity relationship to estimate aquatic toxicity from chemical structure. Using five major classes of industrial chemicals from the Toxic Substances Control Act (TSCA) inventory, this paper presents a structure-activity relationship between the 96-h LC/sub 50/ with fathead minnows and the n-octanol/water partition coefficient which can be computed from structure. Common industrial alcohols, ketones, alkyl halides, ethers, and benzenes are shown to cause lethality by the same mode of action of narcosis. Consequently, a single bilinear equation can predict adequately the 96-h LC/sub 50/ of all classes of industrial chemicals to fathead minnows.
- Research Organization:
- U.S. Environmental Protection Agency, Environmental Research Laboratory-Duluth, Duluth, MN
- OSTI ID:
- 6492078
- Report Number(s):
- CONF-8110103-
- Journal Information:
- Am. Soc. Test. Mater., Spec. Tech. Publ.; (United States), Journal Name: Am. Soc. Test. Mater., Spec. Tech. Publ.; (United States) Vol. STP-802; ISSN ASTTA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
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Consumption
& Utilization-- Industrial & Agricultural Processes-- Industrial Waste Management
520200 -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550200 -- Biochemistry
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ALCOHOLS
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CLASSIFICATION
COMPUTER CALCULATIONS
DRUGS
EQUATIONS
FISHES
HALIDES
HALOGEN COMPOUNDS
HYDROXY COMPOUNDS
INDUSTRIAL WASTES
KETONES
NARCOTICS
OCTANOLS
ORGANIC COMPOUNDS
POLLUTION
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
VERTEBRATES
WASTES
WATER POLLUTION