Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene

Journal Article · Tue Feb 01 04:00:00 EST 1994 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1994.1088· OSTI ID:6483436

Engle, L J; Kennett, R H ^[1]

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1. Univ. of Pennsylvania School of Medicine, Philadelphia, PA (United States)

The mouse dilute gene encodes a novel type of non-muscle myosin that structurally combines elements from both nonmuscle myosin type I and nonmuscle myosin type II. Phenotypically, mutations in the mouse dilute gene result not only in the lightening of coat color, but also in the onset of severe neurological defects shortly after birth. This may indicate that the mouse dilute gene is important in maintaining the normal neuronal function in the mouse. The authors report the isolation and sequencing of [open quotes]myoxin[close quotes] (MYH12), the human homologue of the mouse dilute gene, and its assignment to human chromosome 15. 35 refs., 6 figs.

• OSTI ID: 6483436
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 19:3; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOTECHNOLOGY
CHROMOSOMES
CLONING
DNA HYBRIDIZATION
DNA SEQUENCING
DNA-CLONING
GENES
GENETIC ENGINEERING
GENETIC MAPPING
GLOBULINS
HUMAN CHROMOSOME 15
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
MYOSIN
NUCLEIC ACID HYBRIDIZATION
ORGANIC COMPOUNDS
PROTEINS
STRUCTURAL CHEMICAL ANALYSIS