Glycogen synthesis in liver and skeletal muscle after exercise: participation of the gluconeogenic pathway

Thesis/Dissertation · Wed Jan 01 04:00:00 EST 1986

OSTI ID:6479085

Johnson, J L

Hepatic glycogenesis occurs by both the uptake of plasma glucose (direct pathway) as well as from gluconeogenesis (indirect pathway). In vitro studies suggest that skeletal muscle can also synthesize glycogen from lactate. The purpose of the present studies was to assess the contribution of the indirect pathway to liver and muscle glycogen synthesis after exercise with various substrata infusions. The authors hypothesis was the contribution of the indirect pathway of hepatic glycogenesis would increase after exercise. To this end, fasted rats were depleted of glycogen by exhaustive exercise; a second group of fasted rats remained rested. Both groups were then infused intravenously with glucose containing tracer quantities of (6-/sup 3/H) and (U-/sup 14/C) glucose for 4 hrs. The ensuing hyperglycemic response was exaggerated in post-exercised rats; whereas, plasma lactate levels were lower than those of nonexercised rats. The percent of hepatic glycogen synthesized from gluconeogenic precursors did not differ between exercised (39%) and nonexercised (36%) rats.

• Research Organization: Louisiana State Univ., New Orleans (USA). Medical Center
• OSTI ID: 6479085
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
DIGESTIVE SYSTEM
EXERCISE
GLANDS
GLUCOSE
GLYCOGEN
HEXOSES
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MONOSACCHARIDES
MUSCLES
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RATS
RODENTS
SACCHARIDES
SYNTHESIS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES