Bone accumulation of the Tc-99m complex of carbamyl phosphate and its analogs
Carbamyl phosphate, an organic moecule containing a single phosphate group, has been used in the therapy of sickle-cell disease. Carbamyl phosphate bound Tc-99m and achieved bone uptake in mice, rabbits, and a human volunteer. By examination of the structural formula, a working hypothesis was developed that predicted that the Tc-99m complexes of the analogous compounds acetyl phosphate, propionyl phosphate, and butyryl phosphate, each carrying single phosphate and carbonyl groups, would also show bone specificity. This was confirmed experimentally. Phosphonoacetic acid is a structural analog of these compounds. The structural analysis also predicted that aminomethylphosphonic acid and phosphoenolpyruvate would not have as avid bone affinity, and this was also confirmed. These compounds represent a new class of bone-seeking agents that have the common properties of a lone phosphate and a carbonyl function. Such agents may permit the synthesis of additional analogs in an effort to obtain optimal affinity in the Tc-99m complexes.
- Research Organization:
- Univ. of Connecticut Health Center, Farmington
- OSTI ID:
- 6477306
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 19:5
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARBAMIC ACID ESTERS
BIOLOGICAL ACCUMULATION
ORGANIC PHOSPHORUS COMPOUNDS
RADIOPHARMACEUTICALS
BONE SEEKERS
SKELETON
SCINTISCANNING
TECHNETIUM 99
ISOMERIC NUCLEI
LABELLED COMPOUNDS
MAN
MICE
RABBITS
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID ESTERS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DRUGS
ESTERS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)