Dual label single photon emission tomography: A new method to assess redistribution in regional coronary blood flow after nitroglycerin

Conference · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6476585

Liu, P; Houle, S; Kimball, B; Burns, R J; Gilday, D; Weisel, R D; Warbick-Cerone, A; Johnston, L; McLaughlin, P R

The authors have developed a new method to quantitate changes in coronary blood flow (CBF) by single photon emission tomography (SPECT) of dual-labelled intracoronary human albumin microspheres (HAM) before and after an intervention. After initial validation in pigs, the authors studied 20 pts in the cath lab with 10 pts receiving saline to serve as controls, and 10 pts receiving nitroglycerin (NTG). Thermodilution coronary sinus flow (CSF) measurements were made at rest and after each intervention. After pacing to mild angina, serial injections of Tc-99m HAM, 40 ..mu..g of NTG or saline, and In-111 HAM were made in the left main coronary artery. After routine coronary arteriography, the pt underwent dual-peak SPECT with the image slices reconstructed along the longitudinal axis of the heart. Quantitative circumferential profiles were made for each slice by plotting the average count per pixel in each 18/sup 0/ segment of the left ventricle. After correction for absolute coronary blood flow, the difference between the pre- and post-NTG profile was obtained, and a significant change took place if it exceeded 2 S.D. from control. The segments were classified into normal, mildly, moderately or severely comprised territories according to upstream coronary anatomy. Results are presented. The authors conclude: (1) SPECT of intracoronary HAM combined with CSF measurement represents a powerful tool in assessing changes in regional CBF after an intervention; (2) By this method, NTG gave preferential redistribution of CBF to the mild and moderately ischemic zones of the heart.

• OSTI ID: 6476585
• Report Number(s): CONF-840619-; TRN: 87-022237
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
BLOOD FLOW
DYNAMIC FUNCTION STUDIES
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
IMAGE PROCESSING
ANATOMY
CARDIOVASCULAR AGENTS
CORONARIES
ISCHEMIA
NITROGLYCERIN
RADIOCARDIOGRAPHY
RADIOISOTOPE SCANNING
RADIOPHARMACEUTICALS
UPTAKE
ARTERIES
BLOOD VESSELS
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL EXPLOSIVES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
ESTERS
EXPLOSIVES
LABELLED COMPOUNDS
NITRIC ACID ESTERS
ORGANIC COMPOUNDS
ORGANS
PROCESSING
TOMOGRAPHY
VASCULAR DISEASES
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