Comparison of thermal clearance measurement of regional cerebral blood flow with radiolabelled microspheres

Journal Article · Fri May 01 04:00:00 EDT 1987 · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.18.3.606· OSTI ID:6472323

Hoehner, P J; Dean, J M; Rogers, M C; Traystman, R J

A thermal clearance technique for measuring cerebral blood flow is described and compared with the radiolabelled microsphere technique. The thermal technique involves measurement of the rewarming curve generated after bolus infusion of 4-5 ml of ice-cold saline into the common carotid artery with a subdural thermistor placed on the parietal cortex. Evaluation of the biexponential decay curves obtained with this technique demonstrated a close correlation with total hemispheric, parietal, and parietal gray blood flow determined by simultaneous microsphere measurement. Despite significant correlations (p less than 0.001), scatter in the data produced a broad 95% confidence interval, thus making interpretation of blood flow with the thermal clearance technique impossible. Furthermore, instrumentation with the thermal probe, which required opening of the dura, blunted the cerebral blood flow response to hypercapnia. We conclude that the major limitations of the thermal clearance technique include: nonhomogeneous clearance function, significant variability, and depression of CO/sub 2/ reactivity. These limitations must be addressed before this technique can be used reliably in the laboratory.

• Research Organization: Johns Hopkins Medical Institutions, Baltimore, MD
• OSTI ID: 6472323
• Journal Information: Stroke; (United States), Journal Name: Stroke; (United States) Vol. 3; ISSN SJCCA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DOGS
ENERGY
HEAT
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MEASURING METHODS
MICROSPHERES
NERVOUS SYSTEM
ORGANS
PHYSIOLOGY
RADIOISOTOPES
TRACER TECHNIQUES
VERTEBRATES